Cagrilintide
Batch #449021
Report #53443
Tested at 10.53mg
RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
About Cagrilintide
Cagrilintide is a long-acting analogue of amylin a naturally occurring peptide that is co-released with insulin. It has been studied for its role in metabolic processes and its potential effects on liver function cardiovascular systems and cellular mechanisms. Research has also explored its use in combination with other compounds for enhancing metabolic pathways with ongoing investigations into its broader biological functions.
| Product Specifications | |
|---|---|
| Application | |
| Appearance | |
| Chemical Formula | |
| PubChem CID | |
| Molecular Weight | |
| Synonyms | |
| Cagrilintide 10mg Storage |
Cagrilintide Research
1. Cagrilintide and Obesity
Cagrilintide is a longer acting form of the natural hormone amylin, prepared to help people lose weight by reducing their appetite and making them feel full for longer. It acts directly with the brain cells to help control appetite and food intake.
Figure: Mean percent change in body weight over 26 weeks by treatment group (cagrilintide doses vs placebo).
In a Phase 2 clinical trial of adults who were overweight or obese, participants received weekly injections of cagrilintide for 26 weeks. The trials found that individuals taking cagrilintide lost more weight substantially, achieving an average reduction of 9.7% by week 26 compared to those in the placebo group, highest dose group lost, on average 10.8 kg, compared to 3.0 kg in the placebo group.
Further evidence came from a large Phase 3 trial involving more than 3,400 overweight or obese adults. In one group of this study, participants were given Cagrilintide alone (2.4 mg per week) for 68 weeks. Cagrilintide users lost significantly more weight than those who received a placebo, and had healthier waist measurements and metabolic profiles over all. This data indicates that Cagrilintide is safe and effective for long-term weight management on its own.
(Source: The New England Journal of Medicine, 2025; REDEFINE 1 ClinicalTrials.gov Identifier: NCT05567796)
These findings demonstrate that when combined with a balanced diet and lifestyle changes, cagrilintide can support durable, sustained weight-loss.
2. Mechanism of Action
Cagrilintide is an imitator of endogenous amylin, which is a peptide that is co-secreted with insulin by pancreatic beta cells. By engaging amylin and calcitonin receptors inside the brain, it slows down stomach emptying, induces satiety and diminishes hunger.
Unlike other anti-obesity drugs, cagrilintide works mainly via central appetite suppression rather than metabolic stimulation, which helps in maintaining the right amount of caloric deficit without changing energy expenditure. In both animals and people, this system promotes a gradual, sustained decrease in food consumption and body weight.
3. Metabolic and Cardiovascular Effects
Cagrilintide has also been shown to have positive effects on markers of metabolic health, such as fasting glucose, insulin resistance and lipids profile. These results suggest that cagrilintide is also able to decrease obesity-related cardiometabolic risks, though dedicated long-term outcomes studies are still needed.
Importantly, decrease in visceral fat mass have also been seen, which theoretically may lead to improved cardiovascular outcomes and increased insulin sensitivity (both major aims of overall obesity management).
4. Safety and Tolerability
Cagrilintide has demonstrated a good safety profile in clinical trials. Gastrointestinal symptoms including nausea, vomiting and constipation were the most common adverse effects — mostly mild to moderate and transient. These reactions were generally mild in severity and most commonly arose during the dosage increase; but went away after some time as treatment continued.
No clinically significant safety concerns were identified in the studies. Laboratory tests, cardiovascular results and findings of electrocardiograms did not change over the treatment period, and no dose-limiting toxicities were seen.
5. Pharmacokinetics and Administration
Cagrilintide has been developed for a single weekly subcutaneous administration because of it’s prolonged half-life, enabling for safe and stable plasma concentrations with weekly dosing. It shows high selectivity to receptors, good bioavailability and low accumulation.
In clinical trials, cagrilintide was administered as an escalating dose of 0.3 to 4.5 mg per week. Gradually raising the dosage might help in reducing stomach-related issues and makes it easier for patients to stay on treatment.
REFERENCES
- 1. Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract 2016;22:1–203.
- 2. Dutta D, Jaisani R, Khandelwal D, Ghosh S, Malhotra R, Kalra S. Role of metformin, Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors, Glucagon-Like Peptide-1 (GLP-1) receptor agonists, and orlistat based multidrug therapy in glycemic control, weight loss, and euglycemia in diabesity:A real-world experience. Indian J Endocr Metab 2019;23:460–7.
- 3. Miras AD, le Roux CW. Mechanisms underlying weight loss after bariatric surgery. Nat Rev Gastroenterol Hepatol 2013;10:575–84.
You ask,
we answer.
Are these peptides quality tested?
Are these peptides quality tested?
Absolutely. Our analytical testing is conducted by Janoshik Analytical, an independent third-party laboratory to verify the identity, purity, and composition of our research products. Each CoA includes purity analysis, peptide sequence confirmation, and date of analysis.
What are typical delivery times?
What are typical delivery times?
Delivery for our free shipping option typically takes 3-5 business days. We ship from right here in the USA to all US addresses. We also provide an option for next day shipping for an extra charge. Please allow 24 hours for processing.
Every package comes with professional packaging, tracking updates via email, and does not require a signature upon delivery.
How should these compounds be stored?
How should these compounds be stored?
Our peptides are shipping in lyophilized form, which is stable at room temperature during transit. Once received, store unopened vials in a cool, dry place.
Are products stable during shipping?
Are products stable during shipping?
Our peptides are shipped in lyophilized (freeze-dried) form, which ensures stability during transit. This powder form is highly stable at room temperature and resistant to temperature fluctuations that occur during shipping.
Research has shown no significant degradation or loss of purity when lyophilized peptides are exposed to room temperature during typical shipping timeframes. Each batch is verified for purity upon production, and our stability testing confirms maintenance of product integrity during standard shipping conditions.
What are your bulk ordering options?
What are your bulk ordering options?
For bulk inquiries and volume pricing, please contact us.
What is your return/refund policy for research peptides?
What is your return/refund policy for research peptides?
All sales are final. Since we're dealing with sensitive research compounds that require strict quality control, we can't accept returns or exchanges.
Questions about your order? We're happy to help - just reach out.
What payment methods do you accept?
What payment methods do you accept?
We accept credit/debit cards, Cash App, and Apple Pay. After you place an order, we'll email you a secure payment link. Please complete payment within 48 hours. Unpaid orders are automatically canceled after that window.
If you don't see the email, check spam/promotion or contact support and we'll resend the link.
Are these peptides legal to buy for research in the USA?
Are these peptides legal to buy for research in the USA?
Yes. When purchased for laboratory/research use only and handled in compliance with all applicable federal, state, and local regulations. We sell reagents labeled “Not for human consumption,” not as drugs or supplements.
Some compounds may be restricted in certain jurisdictions. The buyer is responsible for knowing and following their local rules.
Do I need a business or institutional account to order?
Do I need a business or institutional account to order?
No. Individual researchers, labs, and institutions can order. During checkout you must confirm research intent and agree to our Terms. For certain items or larger orders, we may request additional verification or documentation and reserve the right to decline orders that don’t meet compliance standards.
What is the shelf life/expiration of unopened vials?
What is the shelf life/expiration of unopened vials?
Each lot lists a best-by/expiration on the vial label and COA. As general guidance, lyophilized peptides stored as directed are typically stable 12–24 months (often longer at –20 °C). Short shipping periods at ambient temperature are normal. Actual stability depends on sequence and storage conditions.