TB-500

Batch #542201Batch #542201
Report #53457Report #53457
Tested at 6.38mgTested at 6.38mg
Size: 5mg
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RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

About TB-500

TB-500 is a synthetic peptide that has been studied for its role in cellular functions and tissue dynamics. Research has explored its potential applications in areas such as tissue regeneration cellular signaling and mechanisms related to cell migration and repair. Its properties have made it a focus of interest in studies on recovery and structural support in biological systems.

Product Specifications

TB-500 (43aa) Lyophilized Powder in 3ml vial.

Application

Research peptide with potential in endothelial and cytoskeletal dynamics research

Appearance

Solid, white powder in 3mL glass ampule

Chemical Formula

C38H68N10O14

PubChem CID

62707662

CAS Number

77591-33-4

Molecular Weight

4963.5 g/mol

Synonyms

Thymosin Beta-4, TB500 43aa

Storage

Store at ≤6°C, sealed, away from heat, light, and moisture.

TB-500 Research

1. TB-500 and Wound Healing 

Many known research studies have been conducted on TB-500 or Thymosin Beta-4 (Tβ4) due to its potential to promote wound healing and repair tissue vitality. A pivotal study published in the Journal of Investigative Dermatology tested this peptide on rats with skin wounds. Both topical and injected (intraperitoneal) TB-500 accelerated wound healing in rats compared to those that received no treatment.

After only four days, there was approximately 42% more new skin cells growth in the group with treatment of TB-500 compared to the control group. On the seventh day, enhancement had risen to about 61% and wound contraction (a decrease in wound size) to almost 11%. The results of these studies indicate that TB-500 facilitates the body's skin cells' repair more quickly and efficiently.

The peptide is beneficial at several points during the healing process; it fights inflammation, speeds up new cell formation and promotes tissue rebuilding. Together,  these effects promote faster healing by strengthening the skin and increasing flexibility more quickly after injury.

 

2. How TB-500 Works 

Scientists found that TB-500 is able to facilitate healing in several ways. In treated wounds, they observed increased angiogenesis (the growth of new blood vessels) and collagen production, both are necessary for the formation of strong and healthy tissue. In laboratory experiments, TB-500 also accelerated how fast skin cells (keratinocytes) migrated to close wounds. Even tiny doses, as low as 10 picograms (pg) were able to boost cell movement two- or three times in just a few hours. This demonstrates how potent TB-500 is for getting cells to the necessary areas.

Researchers believe this effect occurs because TB-500 interacts with the actin cytoskeleton, which dictates how the cells move and alter shape. TB-500 enhances the movement and organization of cells so they come together to form new skin or blood vessels more quickly.

 

3. Research Findings and What They Mean

The animal and laboratory research is a compelling proof that TB-500 could improve wound healing and stimulate the growth of damaged tissue. It aids in several processes at once, including the formation of new vessels, the buildup of collagen and faster skin growth, which has helped to make it a promising candidate for regenerative medicine.

But the research was conducted in rats and cell cultures, not humans. Early results are positive, but more research is needed to determine the safety, correct dosage and effectiveness in people. The application method of this study (topical and intralesional) may also vary from the way it may be used in clinical practice later.

In general, TB-500 has shown itself as a great healing agent and recovery peptide! Investigations are currently being conducted in hopes that it may be used for wound care, tissue regeneration, and recuperation from injury.

 

Source: Journal of Investigative Dermatology, 1999.


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