GHRP-2
Batch # 344910
Report # 53445
Tested at 99.17% purity
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RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
About GHRP-2
Synthetic hexapeptide utilized in laboratory investigations of ghrelin receptor (GHS-R1a) binding mechanisms and growth hormone secretagogue pathways. GHRP-2 serves as a research tool for examining peptide-receptor interactions, comparative binding affinity studies, and cellular signaling cascade analysis.
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1) Clinical Overview
GHRP-2 (sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂) is a synthetic growth hormone secretagogue (GHS) that agonizes the ghrelin receptor (GHS-R1a), stimulating pituitary GH release via a pathway distinct from GHRH and often synergistic with it. In addition to somatotropic effects, human studies show small, context-dependent rises in ACTH/cortisol and prolactin—evidence of hypothalamic involvement. In Japan, the GHRP-2 drug pralmorelin is approved as a diagnostic GH-stimulation agent (GHRP Kaken 100 for Injection).
2) Human Clinical Findings
Robust GH release; dose response; non-GH pituitary effects. In young and elderly adults, IV GHRP-2 (1–2 μg/kg) provoked strong, dose-related GH rises exceeding those from standard GHRH; both PRL and ACTH/cortisol also increased modestly (less PRL than TRH; ACTH/cortisol similar to hCRH).
Synergy with GHRH; sustained infusions; 30-day study. In healthy adults, GHRP-2 + GHRH showed clear synergy acutely and during 24-h co-infusion; 30 days of continuous SC GHRP-2 (1 μg/kg·h) in older men and women increased pulsatile GH secretion (>3× on day 1; ~1.8× by day 30) and raised IGF-1, IGFBP-3, and IGFBP-5, with routine safety labs remaining normal.
Intranasal route and pediatrics. In children with short stature, intranasal GHRP-2 (5–20 μg/kg) elicited significant GH rises; GHRH + GHRP-2 was synergistic. Longer pediatric programs (intranasal spray) have reported growth-rate improvements, though broader peer-review and replication are limited.
Appetite/energy intake. In lean men, SC GHRP-2 infusion (1 μg/kg·h) for 270 min increased ad libitum food intake ~36% vs saline and raised circulating GH-mirroring ghrelin-like orexigenic effects.
Physiologic modulators. BMI, sex, gonadal status, and L-arginine can modulate GHRP-2/GHRH synergy and GH amplitudes in adults.
3) Mechanism & Effects
GHRP-2 activates GHS-R1a (the ghrelin receptor), driving GH release at pituitary somatotrophs and via hypothalamic circuits (functional antagonism of somatostatin and facilitation of endogenous GHRH likely contribute), which explains synergy with exogenous GHRH. Beyond GH, transient ACTH/cortisol and PRL rises occur in some protocols. The hexapeptide’s sequence and pharmacology are well described in receptor/ligand literature and peptide catalogs.
4) Safety & Considerations
Short-term trials (diagnostic dosing; controlled infusions) generally report good tolerability with predictable endocrine shifts (↑GH; occasional ↑ACTH/cortisol/PRL), and normal routine safety labs in the 30-day SC study of older adults. Long-term safety outside trials remains insufficiently defined.
Regulatory status / quality: Pralmorelin is an approved diagnostic in Japan (injectable). Products sold online for non-diagnostic use are unregulated; quality (identity, sterility, endotoxin) can vary.
FDA cautions (U.S. compounding context): FDA has noted reports (causality not established) of adverse events in recipients of GHRP-2, including altered insulin needs, infection, pancreatitis, and deaths in critically ill subjects—underscoring the need for medical oversight in any research use.
Sport / anti-doping: GHRP-2 (pralmorelin) and all GHRPs are prohibited at all times under WADA S2 (Peptide hormones, growth factors, related substances).
References
- Comparative endocrine effects: Arvat E, et al. Effects of GHRP-2 and hexarelin on GH, PRL, ACTH, cortisol in man. J Endocrinol Invest. 1997. (Dose/age effects; ACTH/cortisol & PRL responses).
- Synergy & extended exposure: Bowers CY, et al. 30-day continuous SC GHRP-2 in older adults; synergy with GHRH; IGF-axis increases. J Clin Endocrinol Metab. 2004.
- Intranasal & pediatric data: Pihoker C, et al. IV and intranasal GHRP-2 in short-stature children; synergy with GHRH. J Clin Endocrinol Metab. 1995.
- Appetite/energy intake: Laferrère B, et al. GHRP-2 increases food intake in healthy men. J Clin Endocrinol Metab. 2005.
- Mechanism / receptor: Reviews on GHS-R1a biology and expression.
- Regulatory/diagnostic: PMDA Japan listing (GHRP Kaken 100—pralmorelin hydrochloride, injection).
- Anti-doping: WADA 2025 Prohibited List—lists GHRP-2 (pralmorelin) among banned GHRPs.
Related Peptides
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we answer.
Are these peptides quality tested?
Are these peptides quality tested?
Absolutely. Our analytical testing is conducted by Janoshik Analytical, an independent third-party laboratory to verify the identity, purity, and composition of our research products. Each CoA includes purity analysis, peptide sequence confirmation, and date of analysis.
What are typical delivery times?
What are typical delivery times?
Delivery for our free shipping option typically takes 3-5 business days. We ship from right here in the USA to all US addresses. We also provide an option for next day shipping for an extra charge. Please allow 24 hours for processing.
Every package comes with professional packaging, tracking updates via email, and does not require a signature upon delivery.
How should these compounds be stored?
How should these compounds be stored?
Our peptides are shipping in lyophilized form, which is stable at room temperature during transit. Once received, store unopened vials in a cool, dry place.
Are products stable during shipping?
Are products stable during shipping?
Our peptides are shipped in lyophilized (freeze-dried) form, which ensures stability during transit. This powder form is highly stable at room temperature and resistant to temperature fluctuations that occur during shipping.
Research has shown no significant degradation or loss of purity when lyophilized peptides are exposed to room temperature during typical shipping timeframes. Each batch is verified for purity upon production, and our stability testing confirms maintenance of product integrity during standard shipping conditions.
What are your bulk ordering options?
What are your bulk ordering options?
For bulk inquiries and volume pricing, please contact us.
What is your return/refund policy for research peptides?
What is your return/refund policy for research peptides?
All sales are final. Since we're dealing with sensitive research compounds that require strict quality control, we can't accept returns or exchanges.
Questions about your order? We're happy to help - just reach out.
What payment methods do you accept?
What payment methods do you accept?
We accept credit/debit cards, Cash App, and Apple Pay. After you place an order, we'll email you a secure payment link. Please complete payment within 48 hours. Unpaid orders are automatically canceled after that window.
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Are these peptides legal to buy for research in the USA?
Are these peptides legal to buy for research in the USA?
Yes. When purchased for laboratory/research use only and handled in compliance with all applicable federal, state, and local regulations. We sell reagents labeled “Not for human consumption,” not as drugs or supplements.
Some compounds may be restricted in certain jurisdictions. The buyer is responsible for knowing and following their local rules.
Do I need a business or institutional account to order?
Do I need a business or institutional account to order?
No. Individual researchers, labs, and institutions can order. During checkout you must confirm research intent and agree to our Terms. For certain items or larger orders, we may request additional verification or documentation and reserve the right to decline orders that don’t meet compliance standards.
What is the shelf life/expiration of unopened vials?
What is the shelf life/expiration of unopened vials?
Each lot lists a best-by/expiration on the vial label and COA. As general guidance, lyophilized peptides stored as directed are typically stable 12–24 months (often longer at –20 °C). Short shipping periods at ambient temperature are normal. Actual stability depends on sequence and storage conditions.
