Ipamorelin
Batch # 453212
Report # 53450
Tested at 10.98mg
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RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
About Ipamorelin
Ipamorelin operates by stimulating the pituitary gland to produce growth-related secretions in animal studies. Additionally it has been observed to reduce the production of somatostatin a secretion that can inhibit growth hormone release. Research also indicates that Ipamorelin may enhance the production of IGF-1 (Insulin-like Growth Factor 1) which is associated with processes involved in the growth and repair of muscular and skeletal tissues.
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1) Clinical Overview
Ipamorelin is a synthetic, selective agonist of the ghrelin (growth-hormone secretagogue) receptor GHS-R1a that triggers pulsatile growth hormone (GH) release with minimal off-target pituitary effects compared with older GHRPs. Mechanistically, it engages the ghrelin receptor on somatotrophs to amplify GH pulses and, secondarily, raise IGF-1. Early pharmacology work emphasized its selectivity for GH over ACTH/cortisol relative to GHRP-2/-6 (preclinical and translational data) . In human volunteers, single-dose PK/PD studies confirm rapid, transient GH stimulation after short infusions of ipamorelin .
Beyond endocrine effects, ipamorelin (as a ghrelin-receptor agonist) has been explored for gastrointestinal motility and other applications; however, clinical development for postoperative ileus was discontinued after a negative phase 2 trial .
2) Human Clinical Findings
a) Healthy volunteers (PK/PD):
A dose-escalation study in healthy men (five 15-min IV infusion rates) found dose-proportional PK and a single GH pulse peaking ~0.67 h post-dose, then declining rapidly. Model-based analysis showed ipamorelin stimulated GH across all dose levels, with short terminal half-life (~2 h) for the drug itself .
b) Post-operative ileus (phase 2 RCT):
In a multicenter, double-blind, placebo-controlled trial (NCT00672074), adults after bowel resection received IV ipamorelin 0.03 mg/kg twice daily up to 7 days. The primary endpoint (time to tolerate a standardized solid meal) did not differ significantly vs placebo (median 25.3 h vs 32.6 h; p=0.15). Safety was acceptable; development for this indication was halted due to lack of efficacy .
3) Mechanism & Effects
Receptor pharmacology: Ipamorelin binds GHS-R1a (ghrelin receptor) to enhance physiologic GH pulsatility; classic reviews summarize GHS-R signaling (e.g., PLC/IP₃ pathways) and the clinical development arc of ghrelin agonists.
Selectivity: Comparative work (notably in swine) showed ipamorelin increased GH without the ACTH/cortisol rises seen with GHRP-2/-6, supporting a more GH-selective profile than earlier GHRPs .
Skeletal effects (preclinical): In rodents, ipamorelin increased bone mineral content and counteracted glucocorticoid-induced reductions in bone formation, consistent with GH/IGF-1–mediated anabolism .
GI motility (mixed): Ghrelin-mimetic activity can accelerate GI transit in animals, but ipamorelin failed to improve recovery endpoints in a human postoperative ileus RCT
4) Safety & Considerations
Short-term exposure in controlled settings (healthy volunteers; surgical inpatients) was generally well tolerated, with no major safety differences vs placebo in the ileus RCT. Ipamorelin is not FDA-approved for any human indication; in 2024, FDA’s compounding advisory review concluded evidence of effectiveness is limited and noted the negative phase 2 trial (development discontinued). The agency also flagged insufficient data for other routes and indications .
For athletes, growth-hormone secretagogues (including ipamorelin) are prohibited under the WADA S2 class of banned substances .
References
- Gobburu JV, Agersø H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin… in human volunteers. Pharm Res. 1999;16(9):1412–1416.
- Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized… ipamorelin for postoperative ileus. Int J Colorectal Dis. 2014;29:1527–1534.
- Raun K, Hansen BS, Johansen PB, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(6):552–561. (preclinical/translation; GH selectivity)
- Ishida J, Saito T. Growth hormone secretagogues: history, mechanism… Receptors Clin Investig. 2020;7:e009. (review)
- Smith RG, Van der Lely AJ, et al. Development of Growth Hormone Secretagogues. Endocr Rev. 2005;26(3):346–370.
- Svensson J, Lall S, Dickson SL, et al. Ipamorelin and GHRP-6 increase bone mineral content in adult female rats. J Endocrinol. 2000;165(3):569–577.
- Andersen NB, Malmlöf K, Johansen PB, et al. Ipamorelin counteracts glucocorticoid-induced decrease in bone formation in adult rats. Growth Horm IGF Res. 2001;11(5):266–272.
- FDA Pharmacy Compounding Advisory Committee. October 29, 2024 Meeting (ipamorelin summary).
- World Anti-Doping Agency (WADA). 2025 Prohibited List (S2: GHS incl. ipamorelin).
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Are these peptides quality tested?
Are these peptides quality tested?
Absolutely. Our analytical testing is conducted by Janoshik Analytical, an independent third-party laboratory to verify the identity, purity, and composition of our research products. Each CoA includes purity analysis, peptide sequence confirmation, and date of analysis.
What are typical delivery times?
What are typical delivery times?
Delivery for our free shipping option typically takes 3-5 business days. We ship from right here in the USA to all US addresses. We also provide an option for next day shipping for an extra charge. Please allow 24 hours for processing.
Every package comes with professional packaging, tracking updates via email, and does not require a signature upon delivery.
How should these compounds be stored?
How should these compounds be stored?
Our peptides are shipping in lyophilized form, which is stable at room temperature during transit. Once received, store unopened vials in a cool, dry place.
Are products stable during shipping?
Are products stable during shipping?
Our peptides are shipped in lyophilized (freeze-dried) form, which ensures stability during transit. This powder form is highly stable at room temperature and resistant to temperature fluctuations that occur during shipping.
Research has shown no significant degradation or loss of purity when lyophilized peptides are exposed to room temperature during typical shipping timeframes. Each batch is verified for purity upon production, and our stability testing confirms maintenance of product integrity during standard shipping conditions.
What are your bulk ordering options?
What are your bulk ordering options?
For bulk inquiries and volume pricing, please contact us.
What is your return/refund policy for research peptides?
What is your return/refund policy for research peptides?
All sales are final. Since we're dealing with sensitive research compounds that require strict quality control, we can't accept returns or exchanges.
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Are these peptides legal to buy for research in the USA?
Are these peptides legal to buy for research in the USA?
Yes. When purchased for laboratory/research use only and handled in compliance with all applicable federal, state, and local regulations. We sell reagents labeled “Not for human consumption,” not as drugs or supplements.
Some compounds may be restricted in certain jurisdictions. The buyer is responsible for knowing and following their local rules.
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Do I need a business or institutional account to order?
No. Individual researchers, labs, and institutions can order. During checkout you must confirm research intent and agree to our Terms. For certain items or larger orders, we may request additional verification or documentation and reserve the right to decline orders that don’t meet compliance standards.
What is the shelf life/expiration of unopened vials?
What is the shelf life/expiration of unopened vials?
Each lot lists a best-by/expiration on the vial label and COA. As general guidance, lyophilized peptides stored as directed are typically stable 12–24 months (often longer at –20 °C). Short shipping periods at ambient temperature are normal. Actual stability depends on sequence and storage conditions.
