L-Glutathione
Batch # 513219
Report # 53447
Tested at 99.8% purity
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RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
About L-Glutathione
L-glutathione is a naturally occurring tripeptide composed of glutamine cysteine and glycine. It has been studied for its role in cellular processes such as antioxidant activity detoxification and maintaining cellular health. Research has focused on its potential involvement in supporting redox balance protecting cells from oxidative stress and participating in various metabolic pathways.
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1. Clinical Overview
L-glutathione (GSH) is a tripeptide (glutamate-cysteine-glycine) and the body’s most abundant intracellular antioxidant. It maintains cellular redox balance, supports phase II detoxification, and modulates immune function. In skin biology, GSH can inhibit tyrosinase and shift melanogenesis toward lighter pheomelanin, mechanisms that help explain its appearance in hyperpigmentation research.
Beyond dermatology, oral GSH has been shown to raise systemic GSH stores and favorably influence oxidative-stress and some metabolic markers in human studies.
2. Human Clinical Findings
Skin pigmentation
• Randomized, double-blind, placebo-controlled trial (n=60, 4 weeks) in healthy adults: oral GSH 500 mg/day (250 mg BID) reduced melanin index at several body sites vs placebo; treatment was well tolerated.
Body GSH stores & immune markers
• RCT (n=54, 6 months): oral GSH 250 or 1000 mg/day increased GSH 30–35% in erythrocytes/plasma/lymphocytes (up to 260% in buccal cells with 1000 mg), lowered oxidized:reduced GSH ratio, and more than doubled NK-cell cytotoxicity at 3 months; values returned to baseline after washout.
• Pilot (n=12, 4 weeks): liposomal GSH 500 or 1000 mg/day raised whole-blood GSH (max ~40%), reduced plasma 8-isoprostane (~35%), and increased NK-cell activity (up to 400%).
Glucose metabolism
• Randomized, double-blind, placebo-controlled trial (n=20, 3 weeks) in obese men with/without type 2 diabetes: oral GSH 1000 mg/day significantly improved whole-body insulin sensitivity by hyperinsulinemic-euglycemic clamp.
• Pragmatic randomized clinical trial in type 2 diabetes (n=250; 6 months): oral GSH 500 mg/day increased blood GSH, reduced 8-OHdG, and in participants ≥55 years lowered HbA1c and increased fasting insulin vs standard care.
3. Mechanism & Effects
GSH directly and indirectly inhibits tyrosinase (e.g., copper chelation at the active site) and can steer melanogenesis toward pheomelanin via thiol-DOPA conjugation, collectively reducing eumelanin production. Its antioxidant action also suppresses ROS-driven melanogenic signaling. Systemically, higher intracellular GSH supports immune cell function and redox homeostasis; oral (including liposomal) forms have demonstrated increases in circulating and cellular GSH in humans.
4. Safety & Considerations
Across short- to mid-term human trials, oral L-glutathione was generally well tolerated, with no serious adverse events reported in healthy adults or in the diabetes studies noted above. Dermatology reviews likewise judge oral/topical use as having a favorable short-term safety profile, though larger, longer trials are still needed.
By contrast, intravenous glutathione for cosmetic skin lightening has limited efficacy data and has drawn safety warnings from regulators and dermatology authors. In 2019, the U.S. FDA highlighted adverse events from compounded injectable glutathione linked to excessive endotoxin contamination and emphasized that dietary-grade glutathione should not be used to compound sterile injectables. Reviews also caution about adverse effects reported with cosmetic IV use and a lack of robust evidence for skin-lightening indications.
References
- Arjinpathana N, Asawanonda P. J Dermatolog Treat. 2012. Oral glutathione as a skin-lightening agent (double-blind RCT).
- Richie JP Jr, et al. Eur J Nutr. 2015. Randomized controlled trial of oral glutathione on body stores and immune markers.
- Sinha R, et al. Eur J Clin Nutr. 2018. Liposomal oral glutathione elevates body stores and immune markers (pilot).
- Søndergård SD, et al. Appl Physiol Nutr Metab. 2021. Oral glutathione improves insulin sensitivity in obese men (RCT).
- Kalamkar S, et al. Antioxidants (Basel). 2022. Long-term oral glutathione in elderly type 2 diabetics (randomized pragmatic trial).
- Sonthalia S, et al. Pigment Int. 2017. Update on glutathione for skin lightening—mechanisms, evidence, and concerns with IV use.
- Lu Y, et al. Biosci Rep. 2021. Review: thioredoxin and glutathione systems in melanogenesis (mechanistic overview).
- U.S. FDA. 2019. Compounding alert: concerns using dietary-ingredient glutathione to compound sterile injectables (endotoxin-related AEs).
Related Peptides
You ask,
we answer.
Are these peptides quality tested?
Are these peptides quality tested?
Absolutely. Our analytical testing is conducted by Janoshik Analytical, an independent third-party laboratory to verify the identity, purity, and composition of our research products. Each CoA includes purity analysis, peptide sequence confirmation, and date of analysis.
What are typical delivery times?
What are typical delivery times?
Delivery for our free shipping option typically takes 3-5 business days. We ship from right here in the USA to all US addresses. We also provide an option for next day shipping for an extra charge. Please allow 24 hours for processing.
Every package comes with professional packaging, tracking updates via email, and does not require a signature upon delivery.
How should these compounds be stored?
How should these compounds be stored?
Our peptides are shipping in lyophilized form, which is stable at room temperature during transit. Once received, store unopened vials in a cool, dry place.
Are products stable during shipping?
Are products stable during shipping?
Our peptides are shipped in lyophilized (freeze-dried) form, which ensures stability during transit. This powder form is highly stable at room temperature and resistant to temperature fluctuations that occur during shipping.
Research has shown no significant degradation or loss of purity when lyophilized peptides are exposed to room temperature during typical shipping timeframes. Each batch is verified for purity upon production, and our stability testing confirms maintenance of product integrity during standard shipping conditions.
What are your bulk ordering options?
What are your bulk ordering options?
For bulk inquiries and volume pricing, please contact us.
What is your return/refund policy for research peptides?
What is your return/refund policy for research peptides?
All sales are final. Since we're dealing with sensitive research compounds that require strict quality control, we can't accept returns or exchanges.
Questions about your order? We're happy to help - just reach out.
What payment methods do you accept?
What payment methods do you accept?
We accept credit/debit cards, Cash App, and Apple Pay. After you place an order, we'll email you a secure payment link. Please complete payment within 48 hours. Unpaid orders are automatically canceled after that window.
If you don't see the email, check spam/promotion or contact support and we'll resend the link.
Are these peptides legal to buy for research in the USA?
Are these peptides legal to buy for research in the USA?
Yes. When purchased for laboratory/research use only and handled in compliance with all applicable federal, state, and local regulations. We sell reagents labeled “Not for human consumption,” not as drugs or supplements.
Some compounds may be restricted in certain jurisdictions. The buyer is responsible for knowing and following their local rules.
Do I need a business or institutional account to order?
Do I need a business or institutional account to order?
No. Individual researchers, labs, and institutions can order. During checkout you must confirm research intent and agree to our Terms. For certain items or larger orders, we may request additional verification or documentation and reserve the right to decline orders that don’t meet compliance standards.
What is the shelf life/expiration of unopened vials?
What is the shelf life/expiration of unopened vials?
Each lot lists a best-by/expiration on the vial label and COA. As general guidance, lyophilized peptides stored as directed are typically stable 12–24 months (often longer at –20 °C). Short shipping periods at ambient temperature are normal. Actual stability depends on sequence and storage conditions.
