Mazdutide
Batch # 425912
Report # 11196
Tested at 99.92% Purity
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RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
About Mazdutide
Mazdutide is an investigational peptide studied at the bench for receptor pharmacology, analytical method development, and in-vitro characterization. This material is supplied for research use only and is not approved for any medical use.
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1. Overview
Mazdutide (also known as IBI362 or LY3305677) is a once-weekly dual-agonist peptide that targets both the GLP-1 receptor and the glucagon receptor. It is being developed to help with obesity, weight control, and type-2 diabetes by reducing body fat, lowering blood sugar, and improving related metabolic markers. PubMed+1
It is currently being tested in China with several Phase II and Phase III clinical trials involving participants with obesity, type 2 diabetes, and metabolic dysfunction. Early studies have shown promising results in reducing body weight and improving glycemic control, with consistent tolerability across different doses. Ongoing research aims to evaluate long-term safety, cardiovascular outcomes, and the peptide’s effectiveness in broader patient populations.
2. Human Clinical Findings
One important study was a Phase II randomized controlled trial in Chinese overweight or obese adults. Participants (n = 248) were assigned to different once-weekly doses of mazdutide (3 mg, 4.5 mg, or 6 mg) or placebo for 24 weeks. The result: mazdutide produced weight loss of –6.7 %, –10.4 %, and –11.3 % for the 3 mg, 4.5 mg, and 6 mg doses respectively, versus a small gain in the placebo group. The drug was well tolerated, with common side effects including nausea, diarrhea, and respiratory-infection symptoms. PubMed
Another trial, called DREAMS-1, focused on Chinese adults with type 2 diabetes inadequately controlled by diet and exercise alone. In doses of 4 mg and 6 mg for 24 weeks, mazdutide delivered significant reductions in HbA1c and improved percentages of participants achieving optimal blood-sugar control compared to placebo. BioSpace
A more recent head-to-head Phase III study (DREAMS-3) compared mazdutide 6 mg once a week to semaglutide 1 mg in Chinese adults with type-2 diabetes and obesity. In that study (349 participants), 48.0 % of mazdutide users achieved the target (HbA1c < 7.0 % and ≥ 10 % body-weight loss), compared to 21.0 % in the semaglutide group. Average body-weight reduction was ~10.29 % for mazdutide vs 6.0 % for semaglutide at week 32.
3. Safety & Considerations
Mazdutide was generally well tolerated in trials up to 24 weeks and beyond. The common side effects were mostly gastrointestinal – such as nausea, diarrhea – and some increase in heart rate at higher doses, but no major safety signals have been reported in published Phase II / III data.
Because it acts on both GLP-1 and glucagon receptors, developers monitor metabolic and cardiovascular markers carefully, especially in long-term trials. To date, the safety profile looks acceptable for the doses studied, but longer term data and broader populations (beyond China) are still pending.
4. Summary
Mazdutide is a promising new peptide-based medicine for obesity and type-2 diabetes, particularly in Chinese populations. Its once-weekly dosing produced meaningful weight loss (8-12 %) in mid-term trials, improved blood sugar control, and was mostly well tolerated. It may have advantages over semaglutide in certain comparisons, but as with any active drug, ongoing monitoring and further Phase III results will determine how it fits into clinical practice.
References
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Phase 2 RCT of mazdutide in Chinese overweight or obese adults. PubMed. PubMed
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DREAMS-1 clinical results at ADA 2025. BioSpace
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DREAMS-3 head-to-head vs semaglutide (Phase III). BioSpace+1
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Systematic review & meta-analysis of mazdutide’s weight-loss effects. Frontiers
Related Peptides
You ask,
we answer.
Are these peptides quality tested?
Are these peptides quality tested?
Absolutely. Our analytical testing is conducted by Janoshik Analytical, an independent third-party laboratory to verify the identity, purity, and composition of our research products. Each CoA includes purity analysis, peptide sequence confirmation, and date of analysis.
What are typical delivery times?
What are typical delivery times?
Delivery for our free shipping option typically takes 3-5 business days. We ship from right here in the USA to all US addresses. We also provide an option for next day shipping for an extra charge. Please allow 24 hours for processing.
Every package comes with professional packaging, tracking updates via email, and does not require a signature upon delivery.
How should these compounds be stored?
How should these compounds be stored?
Our peptides are shipping in lyophilized form, which is stable at room temperature during transit. Once received, store unopened vials in a cool, dry place.
Are products stable during shipping?
Are products stable during shipping?
Our peptides are shipped in lyophilized (freeze-dried) form, which ensures stability during transit. This powder form is highly stable at room temperature and resistant to temperature fluctuations that occur during shipping.
Research has shown no significant degradation or loss of purity when lyophilized peptides are exposed to room temperature during typical shipping timeframes. Each batch is verified for purity upon production, and our stability testing confirms maintenance of product integrity during standard shipping conditions.
What are your bulk ordering options?
What are your bulk ordering options?
For bulk inquiries and volume pricing, please contact us.
What is your return/refund policy for research peptides?
What is your return/refund policy for research peptides?
All sales are final. Since we're dealing with sensitive research compounds that require strict quality control, we can't accept returns or exchanges.
Questions about your order? We're happy to help - just reach out.
What payment methods do you accept?
What payment methods do you accept?
We accept credit/debit cards, Cash App, and Apple Pay. After you place an order, we'll email you a secure payment link. Please complete payment within 48 hours. Unpaid orders are automatically canceled after that window.
If you don't see the email, check spam/promotion or contact support and we'll resend the link.
Are these peptides legal to buy for research in the USA?
Are these peptides legal to buy for research in the USA?
Yes. When purchased for laboratory/research use only and handled in compliance with all applicable federal, state, and local regulations. We sell reagents labeled “Not for human consumption,” not as drugs or supplements.
Some compounds may be restricted in certain jurisdictions. The buyer is responsible for knowing and following their local rules.
Do I need a business or institutional account to order?
Do I need a business or institutional account to order?
No. Individual researchers, labs, and institutions can order. During checkout you must confirm research intent and agree to our Terms. For certain items or larger orders, we may request additional verification or documentation and reserve the right to decline orders that don’t meet compliance standards.
What is the shelf life/expiration of unopened vials?
What is the shelf life/expiration of unopened vials?
Each lot lists a best-by/expiration on the vial label and COA. As general guidance, lyophilized peptides stored as directed are typically stable 12–24 months (often longer at –20 °C). Short shipping periods at ambient temperature are normal. Actual stability depends on sequence and storage conditions.
